Zeno Acne Clearing Device

ZENO Acne Clearing Device is a new breakthrough product clinically proven to make
pimples disappear fast. In fact, for treating acne blemishes, it's the most scientifically
advanced and effective device available without a prescription. ZENO is for patients with
mild to moderate acne and delivers remarkable results within 24 hours.

Zeno is a hand-held battery-operated device designed with a tip that heats to a pre-set
temperature.  The biocompatible tip is designed for direct contact with a blemish on the
skin.  Once in contact with a blemish, the tip will transfer heat into the follicle.  An
internal PID controller chip continually modulates the temperature to a fixed range even
under different skin and circulation conditions by adjusting the flow of energy to match
precisely the heat absorption of the individual user.  Zeno’s microprocessor adapts not
only to your individual skin type but also to the heat absorption characteristics of the
location of the pimple.

Your Zeno adapts to you!  An integral digital timer controls the treatment time. The level
of heat does not cause skin damage.
Specifically, Zeno stimulates a heat-shock response in p. acnes, the bacteria causing
at least 90% of all acne blemishes. Heat shock proteins, activated by bacterial cells
under heat stress, cause the self-destruction of p. acnes within the lesion, reducing
inflammation and allowing the skin to return to a healthy state.

With Tyrell's (ZENO) ClearPoint™ acne heat treatment technology, P. acnes is
destroyed by a process called heat shock response. Heat shock response is a reaction
bacteria have to heat whereby they transcript a number of their genes and activate heat-
shock proteins. These heat-shock proteins participate in the bacteria's death by
causing the bacteria to self-destruct. P. acnes self-destructs in the acne lesion
preventing infection and allowing the skin to return to a healthy state. Fortunately, the
level of heat required is not sufficient to cause damage to the skin.

Tyrell performed numerous lab studies on P. acnes to assess the temperature range in
which heat shock response occurs in this bacteria, including a waterbath and a thermal
cycler study, known for accuracy to tenths of a degree. DNAtrix, Inc., a molecular
pharmaceutical company jointly owned by Dr. Conrad and the Board of Regents of the
University of Texas , performed the thermal cycler testing which was critical in
determining if P. acnes ' heat shock response occurs below the point of heat damage
of human skin. Futhermore, these tests were critical in assessing the rate of P. acnes
death at various temperatures over time (temperature versus time). The results
indicated significant death of P. acnes at a temperature well below the thermic damage
of human skin.